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目的:通过表面处理后钛合金假体动物实验,从生物力学角度评价其生物活性,为假体表面活化技术评价和改进提供实验依据。方法:选取12只健康成年大狗,随机分成两个时间组,全麻后于双侧股骨植入经表面处理后的钛合金假体材料及未经表面处理的钛合金材料,分别于术后8周及12周静脉注射处死大狗,取出假体,通过推出实验方法对不同表面处理进行生物力学评价。结果:各种植入体均具有良好的组织相容性。碱热处理后假体生物力学测试推出实验所需最大推出力较其他组高,显示碱热处理与宿主骨结合界面的剪切强度大于其他表面处理假体。结论:实验中采用碱热处理技术植入物可有效使骨与假体界面之间较早达到牢固固定,有临床价值,在假体的制造过程中应予以重视。
OBJECTIVE: To evaluate the bioactivity of biomimetic titanium alloy by surface treatment and to provide an experimental basis for the evaluation and improvement of prosthetic surface activation technology. Methods: Twelve healthy adult dogs were randomly divided into two groups. After general anesthesia, titanium alloy prosthesis and titanium alloy without surface treatment were implanted into bilateral femur, Big dogs were killed by intravenous injection at weeks 8 and 12, and the prosthesis was removed. Biomechanical evaluation of different surface treatments was conducted by the introduction of experimental methods. Results: All implants had good histocompatibility. The maximum ejecting force required for biomechanical testing of prostheses after alkali heat treatment was higher than that of other groups, indicating that the shear strength of the interface between alkali heat treatment and host bone was greater than that of other surface treated prostheses. CONCLUSIONS: In the experiment, alkali-heat treatment implants can effectively fix the interface between bone and prosthesis earlier and have clinical value. Therefore, attention should be paid to the prosthesis manufacturing process.