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目的分析脾酪氨酸激酶(Syk)在宫颈癌组织中的表达,探讨其与临床病理特征之间的关系。方法采用免疫组织化学方法(PV-6000法)检测46例宫颈癌及15例宫颈正常组织中Syk蛋白的表达,分析其与临床病理特征之间的关系。结果 Syk蛋白在宫颈癌组织中的阳性表达率明显低于正常宫颈组织(P<0.01);Syk蛋白在宫颈癌中的表达与肿瘤的组织分化程度、肌层浸润深度及淋巴结转移相关(P<0.05)。结论 Syk可能在宫颈癌的发生、侵袭、转移过程中起重要作用,监测Syk对评价宫颈癌的转移、指导治疗以及判断预后具有重要价值。
Objective To analyze the expression of spleen tyrosine kinase (Syk) in cervical cancer and to explore its relationship with clinicopathological features. Methods The expression of Syk protein in 46 cases of cervical cancer and 15 cases of cervical normal tissue was detected by immunohistochemical method (PV-6000 method), and its relationship with clinicopathological features was analyzed. Results The positive expression rate of Syk protein in cervical cancer was significantly lower than that in normal cervical tissue (P <0.01). The expression of Syk protein in cervical cancer was correlated with tumor differentiation, depth of myometrial invasion and lymph node metastasis (P < 0.05). Conclusion Syk may play an important role in the development, invasion and metastasis of cervical cancer. Syk monitoring is of great value in evaluating the metastasis, guiding treatment and prognosis of cervical cancer.