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目的：探讨被动吸烟对母体及胎儿的危害。方法：利用妊娠小鼠被动吸烟模型及临床病例对照研究。结果：小鼠整个孕期被动吸烟，每窝胎仔数较孕中期后被动吸烟及对照组明显减少，差异显著（Ｐ＜００１），被动吸烟孕鼠骨髓细胞及胎鼠嗜多染红细胞微核率高于母鼠。被动吸烟孕产妇胎儿宫内生长发育迟缓发生率及早产、新生儿窒息发生率均高于无被动吸烟孕产妇，差异显著（Ｐ＜００１）。１０例被动吸烟孕产妇外周血姐妹染色单体互换较对照组明显升高（Ｐ＜００１）。结论：被动吸烟对母体及胎儿的遗传物质均有损伤作用。
Objective: To investigate the harm of passive smoking to maternal and fetus. Methods: Using passive smoking model in pregnant mice and clinical case control study. Results: Passive smoking throughout the pregnancy, the number of litter per litter than the second trimester of passive smoking and the control group was significantly reduced (P <0 01), passive smoking pregnant mouse bone marrow cells and fetal rat polychromatic erythrocyte micronuclei Rate is higher than that of female rats. The incidence of fetal growth retardation and the incidence of premature birth and neonatal asphyxia in passive smoking pregnant women were significantly higher than those in pregnant women without passive smoking (P <001). Peripheral blood sister chromatid exchange in 10 pregnant women with passive smoking was significantly higher than that in control group (P <001). Conclusion: Passive smoking has damaging effects on maternal and fetal genetic material.