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目的:探讨突变型p53(mutp53)和尼克酰胺磷酸核糖转移酶(Nampt)在胃癌组织中的表达及其对患者预后的影响。方法:用免疫组化法检测68例胃癌患者胃癌组织及癌旁正常胃黏膜组织中p53(免疫组化检测到的p53主要为mutp53)与Nampt的表达,分析mutp53与Nampt表达与患者临床病理因素及预后的关系。结果:胃癌组织中mutp53与Nampt的阳性表达率均明显高于癌旁正常胃黏膜组织(均P<0.05);mutp53的高表达与肿瘤大小、浸润深度、淋巴结转移及TNM分期有关,而Nampt的高表达与肿瘤浸润深度、淋巴结转移及TNM分期有关(均P<0.05)。胃癌组织中,p53表达与Nampt表达呈明显正相关(r=0.982,P<0.05)。p53阳性表达患者的中位生存期明显短于阴性表达患者,且在p53阳性表达患者中,Nampt同时阳性患者的中位生存期明显短于Nampt阴性患者(均P<0.05)。结论:mutp53与Nampt的表达均与胃癌的恶性生物学行为相关,且两者存在一定的关联性,同时高表达患者预后差。
Objective: To investigate the expression of mutant p53 (mutp53) and nicotinamide phosphoribosyltransferase (Nampt) in gastric carcinoma and its effect on the prognosis of patients. Methods: The expression of p53 (mainly p53 and p53) was detected by immunohistochemistry in 68 cases of gastric cancer and adjacent normal gastric mucosa. The expressions of mutp53, Nampt and clinicopathological factors And prognosis. Results: The positive rates of mutp53 and Nampt in gastric cancer tissues were significantly higher than those in normal gastric mucosa tissues (all P <0.05). The high expression of mutp53 was related to tumor size, depth of invasion, lymph node metastasis and TNM staging. However, High expression of tumor invasion depth, lymph node metastasis and TNM staging (P <0.05). In gastric cancer, p53 expression was positively correlated with Nampt expression (r = 0.982, P <0.05). The median survival of patients with p53 positive expression was significantly shorter than that of negative patients, and the median survival of patients with positive p53 expression was significantly shorter than that of negative patients (all P <0.05). CONCLUSION: Both mutp53 and Nampt expression are correlated with the malignant biological behavior of gastric cancer, and there is a certain correlation between the two. Meanwhile, the prognosis of patients with high expression is poor.