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本研究探讨十一酸睾酮抗雄性大鼠生育的机制。１２周龄雄性ＳＤ大鼠，给药组８只每２周注射２０ｍｇ／ｋｇ十一酸睾酮，共３个月。与１０只对照大鼠比较，十一酸睾酮处理大鼠睾丸网液中精子密度下降到对照组的７％，附睾尾部精子活动力下降至对照组的６％，血清睾酮水平上升至对照组的２５５％，而睾丸网液睾酮却下降至对照组的５５％。两组之间均有非常显著差异。未发现十一酸睾酮处理大鼠睾丸生殖细胞和附睾上皮细胞凋亡状况有明显改变，但睾丸和附睾的雄激素受体基因表达显著低于对照组大鼠。十一酸睾酮抑制睾丸精子生成和降低附睾精子活动力可能与睾丸网液的雄激素水平下降以及睾丸和附睾雄激素受体基因表达的抑制有关。
This study explored the mechanism of testosterone undecanoate anti-male rats. Twelve-week-old male Sprague-Dawley rats were injected with 20 mg / kg of testosterone undecanoate every 8 weeks for a total of 3 months. Compared with 10 control rats, testicular sera undecanoate testosterone decreased sperm concentration in the testicular fluid to 7% of the control group, sperm motility in the tail of the epididymis decreased to 6% of the control group, serum testosterone levels rose to control 255%, while testicular fluid testosterone dropped to 55% of the control group. There was a very significant difference between the two groups. The apoptotic status of testis germ cells and epididymal epithelium was not observed in testis testosterone-treated rats, but the expression of androgen receptor gene in testis and epididymis was significantly lower than that in control rats. Testosterone undecanoate inhibits testicular spermatogenesis and decreases sperm motility in the testis may be related to decreased testicular nephropathy and androgen and testis and the epididymis androgen receptor gene expression inhibition.