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目的探讨膀胱癌组织中c-Met的表达及意义。方法选取60例膀胱癌组织病理标本(观察组)与60例正常膀胱组织病理标本(对照组),均进行c-Met表达的免疫组化实验分析。结果 c-Met在观察组中的阳性表达率为60.0%(36/60),明显高于对照组的6.7%(4/60)(P<0.05)。在60例膀胱癌组织中,c-Met在不同病理分级、临床分期与淋巴结转移组织中的阳性表达率比较差异有统计学意义(P<0.05)。结论 c-Met在膀胱癌中呈现高表达状况,能反映膀胱癌组织的病理分级、临床分期与淋巴结转移情况,具有很好的分析价值。
Objective To investigate the expression and significance of c-Met in bladder cancer. Methods 60 cases of bladder cancer tissue samples (observation group) and 60 cases of normal bladder tissue pathological specimens (control group) were selected for immunohistochemical analysis of c-Met expression. Results The positive rate of c-Met in the observation group was 60.0% (36/60), which was significantly higher than that in the control group (6.7%, 4/60) (P <0.05). In 60 cases of bladder cancer, the positive expression rate of c-Met in different pathological grade, clinical stage and lymph node metastasis was significantly different (P <0.05). Conclusions c-Met is highly expressed in bladder cancer and can reflect the pathological grade, clinical stage and lymph node metastasis of bladder cancer, which has a good analytical value.