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对53个至少双亲之一患高血压病(EHT)的家庭和25个正常血压(NT)者家庭(包括父、母及一个子女)成员的红细胞(RBC)Na ̄+-Li ̄+逆向转运(SLC)及Na ̄+-K ̄+同向协同转运(SPT)功能,作它们与平均血压(MABP)间的家庭内部相关分析,并计算其多基因累加遗传力(h2),发现:(1)在NT、NT+EHT家庭,RBC的SPT和SLC的双亲均值都和其子女的相应值呈正相关,但配偶间不相关,提示系遗传性传递;(2)SPT和SLC的h ̄2在NT和NT+EHT家庭分别为0.3250、0.4514和0.5770、0.7829,SLC的h ̄2较SPT的大;(3)双亲SLC均值与子女的MABP呈正相关,而SPT则不相关,提出SLC与血压遗传间的联系较SPT密切,可能成为预测EHT的“遗传标记”;(4)SLC与SPT值均存在“母体效应”。
Na ~ + -Li ~ + antiporter was performed on 53 RBC patients (at least two parents) with hypertension (EHT) and 25 members of the normotensive (NT) family (including parent, mother and one child) (SLC) and Na ~ + -K ~ + co-transport (SPT) function were used to analyze the internal correlations between them and mean blood pressure (MABP), and to calculate the multiplicative heritability (h2) 1) In the NT, NT + EHT families, both Parents’ mean of SPT and SLC of RBC are positively correlated with the corresponding values of their children, but spouses are not related, suggesting hereditary transmission; (2) And NT + EHT families were 0.3250,0.4514 and 0.5770,0.7829, respectively, and SLC h ~ 2 was larger than SPT. (3) There was a positive correlation between parents’ SLC mean and their children’s MABP, while SPT was not related, Proposed SLC and blood pressure genetic link between close than SPT It may become a “genetic marker” Prediction of EHT; (4) SLC SPT values are present with the “maternal effect.”