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目的:探讨壳聚糖吸附澄清是否可以取代醇沉用于丹芪偏瘫胶囊的纯化工艺。方法:采用HPLC-ELSD法对分别采用醇沉与壳聚糖吸附澄清工艺的丹芪偏瘫胶囊中黄芪甲苷含量进行测定。结果:壳聚糖澄清法与醇沉法均能使药液澄清,但是后者更能保留黄芪甲苷这一有效成分。结论:单以黄芪甲苷含量作为指标,壳聚糖澄清法不能取代醇沉法用于丹芪偏瘫胶囊的纯化。
Objective: To investigate whether chitosan adsorption clarification can replace alcohol precipitation for the purification of Danqi hemiplegia capsule. Methods: The contents of Astragaloside Ⅳ in Danqi Hepatic Plexus Capsule with alcohol precipitation and chitosan adsorption-clarification process respectively were determined by HPLC-ELSD. Results: Chitosan clarification method and alcohol precipitation method can clarify the liquid, but the latter is more able to retain the active ingredient of Astragaloside IV. Conclusion: Astragaloside alone as an indicator, chitosan clarification method can not replace alcohol precipitation method for Danqi hemiplegia capsule purification.