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目的:探讨慢性心力衰竭伴二尖瓣返流(MR)患者血浆N末端脑钠肽前体(NT-proBNP)水平与MR的相关性。方法:心脏超声检测MR后将74例慢性心力衰竭患者并分为MR组(35例)和非MR组(39例),采用酶联免疫吸附法(ELISA)检测血浆NT-proBNP水平,观察两组NT-proBNP水平的差异及其与MR的相关性。结果:MR组和非MR组NT-proBNP水平分别为331.7、135.0 pg/mL,两组比较,差异有统计学意义(P<0.05);LVEF与NT-proBNP水平呈负相关(P<0.05),体质量及MR与NT-proBNP水平与呈正相关(P<0.05)。MR与NT-proBNP偏相关系数为0.672(P<0.05);心功能分级与NT-proBNP偏相关系数为0.737(P<0.05);体质量与NT-proBNP偏相关系数为0.638(P<0.05)。结论:MR是影响老年慢性心力衰竭患者NT-proBNP水平的独立因素。
Objective: To investigate the relationship between plasma N-terminal pro brain natriuretic peptide (NT-proBNP) level and MR in patients with chronic heart failure and mitral regurgitation (MR). Methods: Totally 74 patients with chronic heart failure undergoing echocardiography were divided into MR group (n = 35) and non-MR group (n = 39). The levels of NT-proBNP in plasma were detected by enzyme linked immunosorbent assay (ELISA) The difference of NT-proBNP level and its correlation with MR. Results: The levels of NT-proBNP in MR group and non-MR group were 331.7 and 135.0 pg / mL, respectively. There was a significant difference between the two groups (P <0.05). The level of NT-proBNP was negatively correlated with LVEF , Body weight and MR and NT-proBNP levels were positively correlated (P <0.05). The correlation coefficient between MR and NT-proBNP was 0.672 (P <0.05). The partial correlation coefficient between NT-proBNP and heart function was 0.737 (P <0.05) . Conclusion: MR is an independent factor affecting the level of NT-proBNP in elderly patients with chronic heart failure.