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目的:研究宫颈薄层液基细胞学检查(TCT)诊断为未明确意义不典型鳞状细胞(ASCUS)及以上病变的临床意义及处理方法。方法:以TCT诊断211例ASCUS及以上病变患者为研究对象,分别行阴道镜评估、镜下活检及高危人乳头瘤病毒(HPV)DNA检查,并对结果进行统计学分析。结果:211例TCT诊断ASCUS及以上病变阴道镜检查宫颈炎92例(43.6%)、CIN I 65例(30.8%)、CINⅡ32例(15.2%)、CINⅢ18例(8.5%)、原位癌4例(1.9%),CIN及原位癌119例(56.4%);TCT检查ASCUS HPV阳性73例(51.4%)、AGC 3例(50.0%)、LSIL 31例(72.1%)、HSIL 15例(83.3%)、SCC 2例(100.0%),SCC、HSIL以多型别HPV复合感染多见。结论:对于ASCUS患者应采用阴道镜、高危型HPV病毒检测,阴道镜、高危型HPV病毒检测对ASCUS的分流均有重要的意义。
Objective: To study the clinical significance and treatment of cervical smear-based cytology (TCT) diagnosed as atypical squamous cell (ASCUS) and above lesions. Methods: Totally 211 patients with ASCUS diagnosed by TCT were enrolled in this study. Colposcopy assessment, microscopic biopsy and high-risk human papillomavirus (HPV) DNA test were performed. The results were statistically analyzed. Results: Totally 92 cases (43.6%) of cervix cervicitis were detected by 211 cases of colitis with ASCUS diagnosed by TCT, 65 cases (30.8%) with CINⅠ, 32 cases (15.2%) with CINⅡ, (51.4%) were diagnosed as ASCUS by TCT, 3 cases (50.0%) were AGC, 31 cases were LSIL (72.1%) and 15 cases were HSIL %), SCC 2 cases (100.0%), SCC, HSIL multi-type HPV infection more common. CONCLUSIONS: Colposcopy, high-risk HPV testing, colposcopy, and high-risk HPV testing for ASCUS patients are important for shunting ASCUS.