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几十年来,人们已认识到充血性心力衰竭(CHF)的机制是伴有神经内分泌激活的血流动力学的改变。目前,越来越多的证据表明免疫系统的激活和持续的炎症反应(尤其是炎症细胞因子网络的失衡)在CHF的发生发展中发挥重要作用。据此,CHF可被看做是免疫激活和循环血中前炎症因子和抗炎因子增加引起的炎症反应的结果。抗炎和免疫调节治疗成为CHF治疗的新方向。
For decades, it has been recognized that the mechanism of congestive heart failure (CHF) is a hemodynamic change accompanied by neuroendocrine activation. At present, more and more evidences indicate that activation of the immune system and persistent inflammatory response (especially the imbalance of the inflammatory cytokine network) play an important role in the development of CHF. Accordingly, CHF can be seen as a result of an inflammatory response caused by an increase in proinflammatory and anti-inflammatory factors in immune activation and circulating blood. Anti-inflammatory and immunomodulatory therapies become new directions for the treatment of CHF.