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探讨红细胞膜钠锂交换活性（ＳＬＣＡ）与胰岛素依赖型糖尿病（ＩＤＤＭ）肾病之间的关系。方法采用Ｃａｎｅｓｓａ建立的方法，测定了１３例ＩＤＤＭ肾病，以及性别、年龄、糖尿病病程和体重指数（ＢＭＩ）等匹配的１２例正常白蛋白尿ＩＤＤＭ患者红细胞膜ＳＬＣＡ。结果ＩＤＤＭ肾病红细胞膜ＳＬＣＡ０．４６（０．３７～０．５４）ｍｍｏｌ·Ｌ－１·ＲＢＣ－１／ｈ显著高于正常白蛋白尿ＩＤＤＭ患者ＳＬＣＡ０．３０（０．２１～０．３９）ｍｍｏｌ·Ｌ－１·ＲＢＣ－１／ｈ（Ｐ＜０．００１）。结论ＳＬＣＡ可能是预测ＩＤＤＭ肾病最早的指标
To investigate the relationship between erythrocyte membrane sodium lithium exchange activity (SLCA) and insulin-dependent diabetes mellitus (IDDM) nephropathy. Methods Thirteen patients with IDDM nephropathy and 12 matched normal albuminuria IDDM patients with gender, age, duration of diabetes mellitus and body mass index (BMI) were enrolled in this study. Results SLCA 0.46 (0.37-0.54) mmol·L-1 · RBC-1 / h in IDDM nephropathy erythrocyte membrane was significantly higher than that in normal albuminuria IDDM patients (0.21-0.39 mmol / L) · L-1 · RBC-1 / h (P <0.001). Conclusion SLCA may be the earliest index to predict IDDM nephropathy