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背景:帕金森病患者有运动诱发电位、事件相关电位、体感诱发电位等多种诱发电位的异常,提示帕金森病患者除锥体外系病变外,其他神经通路功能也受累。目的:研究帕金森病患者脑干听觉诱发电位(brainstemauditoryevokedpotential,BAEP)和视觉诱发电位(visualevokedpotential,VEP)的变化及其与临床智能障碍表现的关系。设计:病例对照研究。单位:上海市杨浦区市东医院。对象:上海市杨浦区市东医院就诊帕金森病患者186例,诊断均符合全国锥体外系疾病研讨会通过的帕金森病诊断标准,除外不支持本病的不典型症状和体征如锥体束征、失用性步态障碍、小脑症状、意向性震颤、凝视麻痹、严重的自主神经功能障碍、明显的痴呆伴有轻度锥体外系症状等,并经头颅CT或MRI、心电图、胸片、肝肾功能等检查除外继发性帕金森综合征。符合以上标准患者70例(帕金森病组),男32例,女38例;年龄49～76岁,平均(62.2±6.4)岁;受教育年限0～15年,平均(8.9±5.5)年;病程1～9年,平均(4.7±2.3)年。正常对照组60例,男28例,女32例;年龄50～69岁,平均(59.9±5.3)岁;受教育年限0～15年,平均(7.7±6.4)年,均为本科体检健康者,均自愿参加。方法:按统一帕金森病评定量表(unifiedParkinson’sdiseaseratingscale,UPDRS)评分调查。智能测定采用长谷川
BACKGROUND: Parkinson’s disease patients have motor evoked potentials, event-related potentials, somatosensory evoked potentials and other evoked potential abnormalities, suggesting that in addition to extrapyramidal lesions in patients with Parkinson’s disease, other neuronal pathways are also involved. Objective: To study the changes of brainsteanotrophic evoked potential (BAEP) and visualevoked potential (VEP) in patients with Parkinson’s disease and their relationship with clinical manifestations of mental retardation. Design: Case-control study. Unit: Yangpu District, Shanghai East Hospital. PARTICIPANTS: 186 patients with Parkinson’s disease were treated in the Shanghai East Hospital of Yangpu District, Shanghai. The diagnosis met the diagnostic criteria of Parkinson’s disease adopted by the National Seminar on Extrapyramidal Diseases except the atypical symptoms and signs that do not support this disease, such as pyramidal tract Signs and disabilities of gait disorders, cerebellar symptoms, intention tremor, gaze paralysis, severe autonomic dysfunction, obvious dementia with mild extrapyramidal symptoms, and by head CT or MRI, electrocardiogram, chest X-ray , Liver and kidney function tests except for secondary Parkinson’s syndrome. According to the above criteria, 70 patients (Parkinson’s disease group), 32 males and 38 females; aged 49 to 76 years, mean (62.2 ± 6.4) years; education years 0 to 15 years, an average of (8.9 ± 5.5) years ; Duration of 1 to 9 years, an average of (4.7 ± 2.3) years. The normal control group of 60 patients, 28 males and 32 females; aged 50 to 69 years, mean (59.9 ± 5.3) years; educational years 0 to 15 years, an average of (7.7 ± 6.4) years, , Volunteered to participate. Methods: According to the unified Parkinson’s disease rating scale (Unified Parkinson’s Rating Scale, UPDRS) score survey. Intelligent determination using Hasegawa