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目的探讨内分泌腺来源的血管内皮生长因子(EG-VEGF)在多囊卵巢综合征(PCOS)患者中的表达变化及其临床意义。方法选取54例多囊卵巢综合征卵巢组织标本(PCOS组)、40例正常卵巢组织标本(正常组),采用免疫组化法(SP)检测两组标本中EG-VEGF和血管内皮生长因子(VEGF)的表达情况。结果 PCOS组卵巢组织标本中EG-VEGF、VEGF光密度值分别为(0.179 4±0.008 5)、(0.176 3±0.009 0),均显著高于正常组的(0.163 8±0.007 2)、(0.162 9±0.008 7),差异均有统计学意义(P<0.05)。PCOS组卵巢组织标本中EG-VEGF、VEGF的阳性表达分布与正常组比较差异均有统计学意义(P<0.05),PCOS组卵巢组织标本中EG-VEGF、VEGF的阳性表达率显著高于正常组(P<0.05)。结论 EG-VEGF在多囊卵巢综合征患者中的表达水平显著升高,其过表达可能与PCOS患者血管生成有关。
Objective To investigate the expression of endocrine-derived vascular endothelial growth factor (VEGF-VEGF) in patients with polycystic ovary syndrome (PCOS) and its clinical significance. Methods 54 cases of PCOS ovarian tissue samples (PCOS group) and 40 cases of normal ovarian tissue samples (normal group) were detected by immunohistochemistry (SP) EG-VEGF and vascular endothelial growth factor VEGF) expression. Results The optical density of EG-VEGF and VEGF in PCOS group were (0.179 4 ± 0.008 5) and (0.176 3 ± 0.009 0) respectively, which were significantly higher than that of the normal group (0.163 8 ± 0.007 2) and (0.162 9 ± 0.008 7), the differences were statistically significant (P <0.05). The positive expression rates of EG-VEGF and VEGF in PCOS group were significantly different from those in normal group (P <0.05). The positive rates of EG-VEGF and VEGF in PCOS group were significantly higher than those in normal group Group (P <0.05). Conclusion The expression of EG-VEGF in PCOS patients is significantly higher than that in PCOS patients.