众所周知，肝胆系统的正常免疫屏障作用，主要是通过Kupffer细胞和抗体产生细胞完成的。在疾病所致的胆道梗阻中，肠内Ig急剧下降，可引起肠免疫防御机能障碍，出现感染性腹泻，肠内细菌易位，甚至发展为肠源性败血症。与胆道梗阻程度显著正相关的血清SIgA水平可作为判断胆道梗 It is well-known that the normal immune barrier function of the hepatobiliary system is accomplished mainly by Kupffer cells and antibody-producing cells. In disease-induced biliary obstruction, a dramatic drop in intestinal Ig can cause intestinal immune defensive dysfunction, infectious diarrhea, intestinal bacterial translocation, and even the development of gut-derived sepsis. The level of serum SIgA, which is significantly positively correlated with the degree of biliary obstruction, can be used as a basis for judging the biliary tract