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高血压病的治疗观念已发生根本性变化,即队传统的以利尿剂或β受体阻断剂为第一线药物的阶梯治疗,变为更灵活的个体化治疗,钙拮抗剂和血管紧张素转换酶抑制剂(ACEI)也被推荐为首选抗高血压药物。为了增加疗效,减少不良反应,在临床上联合药物疗法是治疗中、重度及有并发症高血压病的常用治疗方法。然而,ACEI与不同钙拮抗剂的个体化联合药物疗法文献报道尚少。为此,我们依据高血压病并发症的有、无及其不同,采取ACEI依那普利(enalapril)分别与钙拮抗剂尼群地平(nitrendipine)、地尔硫(艹卓)(diltiazem)、尼莫地平(nimodipine),联合治疗高血压病并对其疗效进行了观察,总结如下。
Hypertension treatment has undergone fundamental changes in the concept that the team’s traditional diuretics or β-blockers as the first-line drugs in the ladder treatment, become more flexible individualized treatment, calcium antagonists and vascular tension Sucrase-converting enzyme inhibitors (ACEI) are also recommended as the preferred antihypertensive drugs. In order to increase the curative effect and reduce the adverse reaction, the combination therapy in the clinic is a common treatment method for the treatment of moderate, severe and complications of hypertension. However, individualized combination therapy with ACEI and different calcium antagonists is still rarely reported in the literature. To this end, we based on the presence and absence of complications of hypertension, ACEI enalapril with calcium antagonist nitrendipine, diltiazem, Nimodipine (nimodipine), combined treatment of hypertension and its efficacy were observed, summarized as follows.