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目的 分析贵州省乙型病毒性肝炎 (乙肝) 免疫策略的实施效果.方法 收集贵州省2003年乙肝疫苗 (Hep B) 纳入免疫规划 (EPI) 后Hep B常规免疫、1994-2007年出生人群查漏补种以及1992年、2006年、2014年1-29岁人群乙肝血清流行病学调查与乙肝报告发病等数据, 比较分析Hep B接种率、乙肝病毒 (HBV) 流行率、HBV表面抗原 (HBs Ag) 流行率.结果 贵州省1992年1-4岁、5-14岁、15-29岁HBV流行率分别为29.92％、44.89％、59.73％, 2014年分别为1.33％、9.32％、34.50％.2006年3个年龄组HBs Ag流行率分别为2.72％、2.94％、6.47％, 2014年分别为0.66％、1.69％、5.00％.2014年3个年龄组Hep B调查接种率分别为100％、82.63％、26.00％.2004-2014年1-29岁人群乙肝发病率为2.38/10万-145.73/10万, 其中1-14岁、15-29岁分别为2.38/10万-28.59/10万、37.36/10万-73.80/10万, 分别比2006年下降79.43％-82.22％、38.87％-48.35％.结论 贵州省Hep B纳入EPI后使1-29岁 (特别是1-14岁) 人群HBV和HBs Ag流行率、乙肝发病率显著下降.“,”Objective To evaluate the effect of the hepatitis B immunization strategy in Guizhou province. Methods We collected data on routine vaccination with hepatitis B vaccine ( HepB), catch-up vaccination for children born in 1994-2007, sero-epidemiological surveys conducted in 1994, 2006, and2014, and hepatitis B case reports since Hep B was introduced into the Expanded Program on Immunization ( EPI) in 2003. We compared Hep B coverage and prevalence of hepatitis B virus ( HBV) and HBV surface antigen ( HBsAg). Results HBV prevalence rates among 1-4, 5-14, and 15-29 year-olds, respectively, were 29. 92％, 44. 89％, and 59. 73％ in 1992, and 1. 33％, 9. 32％, and 34. 50％ in2014. HBsAg positivity rates among the 3 age groups, respectively, were 2. 72％, 2. 94％, 6. 47％ in 2006, and 0. 66％, 1. 69％, and 5. 00％ in 2014. Hep B coverage rates among the 3 age groups were100％, 82. 63％, and 26. 00％ in 2014, respectively. Incidence rates of hepatitis B ranged 2. 38-145. 73 per 100 000 population among 1-29 year-olds during 2004-2014, with 2. 38-28. 59 per 100 000 for 1-14 year-olds and 37. 36-73. 80 per 100 000 for 15-29 year-olds, representing decreases of 79. 43％-82. 22％ and 38. 87％-48. 35％, respectively, compared with in 2006. Conclusions HBV and HBs Ag prevalence and hepatitis B incidence significantly decreased among 1-29 year-olds ( especially 1-14 yearolds) after introduction of Hep B into EPI in Guizhou.