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为了探讨消炎痛宫内节育器（ＩＵＤ）对子宫内膜的影响，给ＳＤ大鼠和新西兰兔经腹放置消炎痛－Ｃｕ－ＩＵＤ、Ｃｕ－ＩＵＤ、消炎痛－ＩＵＤ或硅橡胶ＩＵＤ，分别于置器后１、３、６个月解剖取子宫，行光镜和电镜观察，并与不放ＩＵＤ动物作对照。结果：消炎痛－Ｃｕ－ＩＵＤ放置１～６个月后子宫内膜无明显病理改变，与对照组相似，消炎痛及硅橡胶ＩＵＤ也都未引起子宫内膜病理改变，Ｃｕ－ＩＵＤ组可见组织水肿、纤维组织增生及散在白细胞等轻度病理变化。血管分布状态有一些变化，消炎痛－ＩＵＤ微血管以正常和收缩状态为主，Ｃｕ－ＩＵＤ则见微循环扩张，以微血管舒张状态为主（７０％），与消炎痛－Ｃｕ－ＩＵＤ组及对照组比较，有显著性差异（Ｐ＜０．０１）。结论：消炎痛对子宫内膜无不良影响
To investigate the effect of indomethacin IUD on endometrium, indomethacin-Cu-IUD, Cu-IUD, indomethacin-IUD or silicone rubber IUD were intraperitoneally placed in SD rats and New Zealand rabbits One, three, six months after the device was dissected, the uterus was dissected and observed with light microscope and electron microscope. Results: The indomethacin-Cu-IUD placed 1 to 6 months after the endometrium no significant pathological changes, similar to the control group, indomethacin and silicone rubber IUD did not cause endometrial pathology, Cu-IUD group visible tissue Edema, fibrous tissue proliferation and scattered white blood cells and other mild pathological changes. There were some changes in the distribution of blood vessels, indomethacin-IUD microvascular in normal and contracted state, Cu-IUD see microcirculation dilation, mainly in the state of micro-vasodilation (70%), indomethacin-Cu-IUD group and control There was significant difference between the two groups (P <0.01). Conclusion: Indomethacin has no adverse effect on the endometrium