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研究了氧化石墨烯(GO)对九芴甲氧羰基二苯丙氨酸(Fmco-FF)自组装行为的调控。探讨不同制样方式、pH、处理温度对Fmoc-FF/GO杂化水凝胶形貌的影响,通过扫描电镜(SEM)、透射电镜(TEM)、原子力显微镜(AFM)观察Fmoc-FF/GO自组装材料微观结构,利用X射线衍射(XRD)、傅里叶变换红外光谱(FT-IR)对其分子结构进行表征,研究了GO调控Fmco-FF自组装的机理。结果表明,GO能够调控Fmoc-FF的自组装行为,得到了不同形貌的自组装结构,包括GO包裹的Fmoc-FF纳米纤维,Fmoc-FF纳米纤维包裹的GO复合体以及GO包裹的Fmoc-FF纳米球等。这有助于理解多肽自主装的机理和GO在多肽自主装中的作用,从而设计功能化的肽类材料。
The effect of GO on the self-assembly of 9-fluorenylmethoxycarbonyl diphenylalanine (Fmco-FF) was investigated. The effects of different preparation methods, pH and treatment temperature on the morphology of Fmoc-FF / GO hydrogel were investigated. The Fmoc-FF / GO hydrogel was observed by scanning electron microscopy (SEM), transmission electron microscopy (TEM) and atomic force microscope The microstructure of self-assembled material was characterized by X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR). The molecular mechanism of Fmco-FF self-assembly was studied. The results showed that GO could regulate the self-assembly behavior of Fmoc-FF and obtained self-assembled structures with different morphologies, including GO-coated Fmoc-FF nanofibers, Fmoc-FF nanofibers-coated GO complexes and GO- FF nanosphere and so on. This helps to understand the mechanism of self-assembly of peptides and the role of GO in peptide assembly, thereby designing functionalized peptide materials.