Wnt信号通路参与细胞的分化、增殖和凋亡,并在多种肿瘤的发生、发展中起着重要作用。Dapper是一类新发现的信号调控分子家族,是散乱蛋白Dishevelled的相互作用蛋白,而散乱蛋白是Wnt信号通路中关键性的正向调控因子。多发性骨髓瘤(MM)的发病机制复杂,在分子生物学上需要许多信号通路参与。该文就Dapper的生物学特性及其在MM发生、发展中的作用研究进行阐述。 Wnt signaling pathway is involved in cell differentiation, proliferation and apoptosis, and plays an important role in the occurrence and development of many tumors. Dapper is a newly discovered family of signal regulation molecules that are Dishevelled interacting proteins of Scattered Protein, which is a key positive regulator of Wnt signaling. The pathogenesis of multiple myeloma (MM) is complex and requires many signaling pathways involved in molecular biology. This article describes the biological characteristics of Dapper and its role in the occurrence and development of MM.