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采用ＥＬＩＳＡ法观察了４０例老年及老年前期高血压病患者血小板表面α－颗粒膜蛋白（ＧＭＰ－１４０）的变化及与内皮损伤、脂质过氧化的关系。结果显示，高血压病组血小板表面ＧＭＰ－１４０、血浆ｖｏｎＷｉｌｅｂｒａｎｄ因子（ＶＷＦ）及血浆脂质过氧化物（ＬＰＯ）与正常人比较均显著增高（Ｐ＜０．０５或Ｐ＜０．００１）。且Ⅱ期患者高于Ⅰ期患者（Ｐ＜０．０５或Ｐ＜０．００１）。血浆超氧化物歧化酶（ＳＯＤ）无明显变化，ＳＯＤ／ＬＰＯ比值显著降低（Ｐ＜０．００１）。高血压病组血小板表面ＧＭＰ－１４０变化与血浆ＶＷＦ、ＬＰＯ呈正相关，与ＳＯＤ／ＬＰＯ比值呈负相关。提示血小板活化可能是高血压病发展过程中的一个重要中间环节。
The changes of platelet α-granule membrane protein (GMP-140) and its relationship with endothelial injury and lipid peroxidation were observed by ELISA in 40 elderly and elderly patients with essential hypertension. The results showed that the platelet surface GMP-140, von Willebrand factor (VWF), and plasma lipid peroxides (LPO) in hypertensive patients were significantly higher than those in normal controls (P <0.05 or P <0.001). And stage Ⅱ patients were higher than stage Ⅰ patients (P <0.05 or P <0.001). Plasma superoxide dismutase (SOD) had no significant change, SOD / LPO ratio was significantly lower (P <0.001). The changes of platelet surface GMP-140 in hypertensive patients were positively correlated with plasma VWF and LPO, but negatively correlated with the ratio of SOD / LPO. Tip platelet activation may be an important intermediate link in the development of hypertension.