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目的:探讨中药周期疗法治疗慢性盆腔炎患者疗效观察。方法:选取本院2013年12月—2015年12月妇产科收治的146例慢性盆腔炎患者为研究对象,对照组予静滴抗生素治疗,观察组在对照组基础上联合中药周期疗法。比较两组血清IL-2、TNF-α水平及CRP等炎症因子水平及全血比黏度(低切)、全血比黏度(高切)、血浆比黏度、纤维蛋白原水平、红细胞聚集指数等血液流变学指标。结果:观察组患者总有效率为87.67%,高于对照组患者总有效率72.60%;治疗前观察组IL-2、TNF-α及CRP分别为(3.12±0.37)ng/m L、(4.27±0.14)ng/m L、(33.28±5.36)g/L,治疗后观察组IL-2、TNF-α及CRP分别为(5.84±1.47)ng/m L、(1.23±0.18)ng/m L、(5.48±3.29)g/L;治疗前对照组IL-2、TNF-α及CRP分别为(3.24±0.38)ng/m L、(4.09±0.32)ng/m L、(32.74±5.08)g/L;治疗后对照组IL-2、TNF-α及CRP分别为(4.28±0.89)ng/m L、(2.35±0.42)ng/m L、(11.25±4.67)g/L;治疗后两组患者CRP及TNF-α均较前下降,且观察组更低,IL-2均较治疗前升高,且观察组升高更明显,差异有统计学意义;治疗前观察组全血比黏度(低切)、全血比黏度(高切)、血浆比黏度、纤维蛋白原水平、红细胞聚集指数分别为(15.6±1.4)、(5.1±0.3)、(2.4±0.8)、(4.9±0.5)、(5.5±1.6),治疗后上述指标分别为(9.4±1.4)、(3.5±0.4)、(1.0±0.3)、(2.3±0.3)、(2.3±0.6);治疗前对照组全血比黏度(低切)、全血比黏度(高切)、血浆比黏度、纤维蛋白原水平、红细胞聚集指数分别为(15.73±2.1)、(5.0±0.6)、(2.1±1.0)、(4.8±0.6)、(5.4±0.7),治疗后上述指标分别为(10.6±2.9)、(3.7±0.6)、(1.4±0.5)、(2.9±0.4)、(3.4±0.8);治疗后,两组患者血液流变学均较前下降,且在血浆比黏度、纤维蛋白原水平、红细胞聚集指数方面,观察组较对照组更低,差异有统计学意义。结论:中药周期疗法可以改善慢性盆腔炎患者血液流变学,降低炎性因子水平,提高疗效。
Objective: To investigate the efficacy of traditional Chinese medicine cyclical therapy in patients with chronic pelvic inflammatory disease. Methods: A total of 146 patients with chronic pelvic inflammatory disease admitted from obstetrics and gynecology department from December 2013 to December 2015 in our hospital were enrolled in this study. Patients in the control group were treated with intravenous antibiotics. The observation group was treated with traditional Chinese medicine cyclotherapy on the basis of the control group. Serum levels of IL-2 and TNF-α, inflammatory cytokines such as CRP, whole blood specific viscosity (low cut), whole blood specific viscosity (high shear), plasma specific viscosity, fibrinogen, erythrocyte aggregation index Hemorheology index. Results: The total effective rate was 87.67% in the observation group and 72.60% in the control group. The levels of IL-2, TNF-α and CRP in the observation group before treatment were (3.12 ± 0.37) ng / m L and ± 0.14) ng / m L and (33.28 ± 5.36) g / L, respectively. The levels of IL-2, TNF-α and CRP in the observation group were (5.84 ± 1.47) ng / m L L and (5.48 ± 3.29) g / L, respectively. The levels of IL-2, TNF-α and CRP in the control group before treatment were (3.24 ± 0.38) ng / m L, ), and the levels of IL-2, TNF-α and CRP in the control group were (4.28 ± 0.89) ng / m L and (2.35 ± 0.42) ng / m L, The CRP and TNF-αin the latter two groups were lower than before, and the observation group was lower, IL-2 was higher than before treatment, and the observation group increased more obviously, the difference was statistically significant; before treatment, the whole blood of the observation group The indexes of specific viscosity (low cut), whole blood specific viscosity (high cut), plasma specific viscosity, fibrinogen level and erythrocyte aggregation index were (15.6 ± 1.4), (5.1 ± 0.3), (2.4 ± 0.8) and ± 3.5, 0.4 ± 0.4, 1.0 ± 0.3, 2.3 ± 0.3, and 2.3 ± 0.6, respectively. Before treatment, the control group Whole blood specific viscosity (low cut), whole blood Viscosity (high shear), plasma specific viscosity, fibrinogen level and erythrocyte aggregation index were (15.73 ± 2.1), (5.0 ± 0.6), (2.1 ± 1.0), (4.8 ± 0.6), (5.4 ± 0.7) After treatment, the above indexes were (10.6 ± 2.9), (3.7 ± 0.6), (1.4 ± 0.5), (2.9 ± 0.4) and (3.4 ± 0.8) respectively. After treatment, , And in the plasma specific viscosity, fibrinogen level, erythrocyte aggregation index, the observation group was lower than the control group, the difference was statistically significant. Conclusion: The traditional Chinese medicine cyclical therapy can improve the hemorrheology, reduce the level of inflammatory cytokines in patients with chronic pelvic inflammatory disease and improve the curative effect.