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系统检测18例服氯氮平的精神分裂症患者血浆药物浓度。结果表明,血药浓度和服药剂量呈正相关;而不同患者血药浓度的个体差异很大。血药浓度和临床疗效以及脑、心电图异常改变均无明显联系。初步讨论了血药浓度检测的临床意义,认为对于某些疗效较差或药物副反应较重的患者,血药浓度测定具有临床参考价值。
Systemic testing of 18 patients taking clozapine schizophrenia plasma drug concentration. The results showed that plasma concentration and medication dose was positively correlated; and different patients with different plasma concentrations of individual differences. Blood concentration and clinical efficacy and brain, ECG abnormal changes were not significantly linked. The clinical significance of plasma concentration test was discussed preliminarily. It is considered that the determination of plasma concentration has clinical value for some patients who have poor curative effect or severe adverse drug reactions.