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目的研究2型糖尿病(T2DM)合并非酒精性脂肪肝(NAFLD)与颈动脉内中膜厚度(IMT)及斑块发生率之间的关系。方法按T2DM患者是否合并NAFLD分为4组:正常对照组、T2DM不合并NAFLD组、T2DM合并轻度NAFLD组、T2DM合并中重度NAFLD组。超声检测各组患者颈动脉IMT,记录斑块数量。结果与正常对照组、T2DM不合并NAFLD组比较,T2DM合并轻度NAFLD组、T2DM合并中重度NAFLD组的颈动脉IMT明显增加,斑块检出率显著升高,差异有统计意义(P<0.05或P<0.01);T2DM合并中重度NAFLD组的颈动脉IMT、斑块检出率显著高于T2DM合并轻度NAFLD组,差异有统计意义(P<0.05或P<0.01)。结论 T2DM合并NAFLD患者的颈动脉IMT及斑块发生率明显增加,且T2DM合并中重度NAFLD的患者增加最为显著。
Objective To investigate the relationship between type 2 diabetes mellitus (T2DM) with non-alcoholic fatty liver disease (NAFLD) and carotid artery intima-media thickness (IMT) and plaque incidence. Methods According to whether T2DM patients with NAFLD were divided into four groups: normal control group, T2DM non-NAFLD group, T2DM combined with mild NAFLD group, T2DM combined with moderate and severe NAFLD group. The carotid IMT of each group was detected by ultrasound and the number of plaque was recorded. Results Compared with normal control group and T2DM without NAFLD group, the carotid IMT in T2DM with mild NAFLD group and T2DM combined with moderate and severe NAFLD group were significantly increased, the plaque detection rate was significantly increased, the difference was statistically significant (P <0.05 Or P <0.01). The IMT detection rate of carotid artery in T2DM with moderate and severe NAFLD was significantly higher than that in T2DM with mild NAFLD (P <0.05 or P <0.01). Conclusions The incidence of carotid IMT and plaque in T2DM patients with NAFLD is significantly increased, and the most significant increase is in patients with T2DM complicated with moderate-to-severe NAFLD.