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当第二次世界大战期间荷兰被占领时,一支来自Nederlandsche Gist-en Spiritusfabriek(即现如今的中化帝斯曼制药有限公司)的团队秘密进行青霉素分离、表征和生产——他们当时的代号为“BACINOL”。这一为期18个月的秘密项目,完全独立于声名远播的美国和英国青霉素生产的技术支持,在极具挑战性的环境下实施,这个秘密团队无法查阅技术文献,也没有确凿数据,更没有那些昂贵的发酵设备。
When the Dutch were captured during World War II, a team from Nederlandsche Gist-Spiritusfabriek (now Sinofert DSM Ltd.) conducted a confidential penicillin separation, characterization and production - their then codename For “BACINOL”. This 18-month clandestine project, completely independent of the venerable U.S. and UK technical support for penicillin production, is being conducted in a challenging environment that does not have access to technical literature or data and more There are no expensive fermentation equipment.