胼胝体变性 (corpus callosum demyelination)是一种少见疾病，又称原发性胼胝体萎缩，或 Marchiafava－ Bignami病，至今病因不明，最早由 Carducc于 1898年报道 [1]发生于饮红葡萄酒的意大利老人。本组 2例与文献报道 6例共 8例 [2～ 4]，患者均为男性，均有嗜酒及长期酗酒所 Corus callosum demyelination is a rare disease, also known as primary corpus callosum atrophy, or Marchiafava-Bignami disease, whose etiology is unknown to date. It was first reported by Carducc in 1898 [1] and occurred in an elderly Italian drink red wine. This group of 2 cases and 6 cases reported in the literature a total of 8 cases [2 ~ 4], patients were men, both alcoholism and chronic alcoholism