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目的探讨高龄孕妇唐氏综合征血清学筛查在产前诊断唐氏综合征缺陷儿中的作用,降低出生缺陷的发病率,提高优生优育;方法高龄孕妇唐氏综合征血清学筛查(唐筛阳性组和唐筛阴性组)中286例行羊膜腔穿刺,羊水细胞培养、染色体核型分析;结果 3634例高龄孕妇中产前筛查唐筛阳性706例(占19.43%),唐筛阴性的单纯年龄高风险孕妇2928例(占80.57%),羊水细胞培养成功率为100%,唐筛阳性者706例孕妇中在超声引导下行羊水穿刺142例,占20.11%;检出率1.42%,唐筛阴性的单纯年龄高风险孕妇2928例中在超声引导下行羊水穿刺144例,占4.92%,检出率0.31%;结论唐筛阳性的高龄孕妇进行羊水穿刺检查能更有效检出唐氏综合征患儿,提高优生优育的质量,降低了出生后婴儿缺陷的发病率,对国家优生优育的政策起到了重要的维护作用。
Objective To investigate the effect of Down’s syndrome serological screening on pregnant women with Down’s syndrome in prenatal diagnosis, reduce the incidence of birth defects and improve prenatal and postnatal care. Methods Serological screening of Down’s syndrome 286 cases of amniocentesis, amniotic fluid cell culture and chromosomal karyotype analysis were performed in 366 cases of pregnant women with prenatal screening screening. Results 706 cases (19.43% 2928 cases (80.57%) were purely age-at-risk pregnant women. The success rate of amniotic fluid cell culture was 100%. Among 706 pregnant women with Tang-positive, 142 cases (20.11%) had amniocentesis under ultrasonic guidance. The detection rate was 1.42% Among 2928 cases of pure age-high risk pregnant women with negative Tang screen, 144 were amniocentesis guided by ultrasound, accounting for 4.92%, with a detection rate of 0.31%. Conclusion Amniotic fluid puncture examination can be more effective in Down’s syndrome screening of pregnant women with Down’s syndrome Zheng children, improve the quality of prenatal and postnatal care, reduce the incidence of infant defects after birth, the national prenatal and postnatal care policies played an important role in maintaining.