原发性胆汁性肝硬变(primarybiliarycirrhosis,PBC)是一种以肝内中、小胆管的非化脓性进行性炎性损伤为特征,最终导致肝硬变和肝衰竭的慢性肝病。至今PBC病因未明,治疗无特异性药物。目前认为PBC属于自身免疫性疾病,与细胞免疫及体液免疫均密切相关,而最近分子模拟机制的提出, Primary biliary cirrhosis (PBC) is a chronic liver disease characterized by non-suppurative progressive inflammatory injury of the middle and small bile ducts leading to cirrhosis and liver failure. PBC etiology has not yet clear, the treatment of non-specific drugs. Currently considered PBC is an autoimmune disease, and cellular immunity and humoral immunity are closely related to the recent molecular simulation mechanism proposed,