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目前,β-肾上腺素能阻断剂(下简称β-阻断剂)已普遍应用于室性心律失常患者。本文评述了β-阻断剂抗室性心律失常的可能机理及临床研究。 β-阻断剂抗心律失常的作用机理 一般认为β-阻断剂抗心律失常的主要作用机理有二:(1)对肾上腺素能兴奋作用的抑制。肾上腺素能的增强可加强心肌纤维起搏点活性而导致心律失常。β-阻断剂通过阻断肾上腺素能的兴奋,降低心肌细胞自律性和起搏点电位的坡度以控制心律失常。当儿茶酚胺(下简称CA)过量或哇巴因存在时,可增强这种作用。(2)膜抑制作用(即
At present, β-adrenergic blockers (beta-blockers) have been widely used in patients with ventricular arrhythmias. This article reviews the possible mechanisms and clinical studies of β-blockers against ventricular arrhythmias. Blocking agents anti-arrhythmic mechanism of action It is generally believed that the main mechanism of action of β-blockers anti-arrhythmia has two: (1) inhibition of adrenergic excitement. Adrenergic enhancement can enhance myocardial fiber pacemaker activity and lead to arrhythmia. Beta-blockers control arrhythmias by blocking the excitability of adrenergic, decreasing cardiomyocyte autonomy, and the slope of the pacemaker potential. When catecholamines (hereinafter referred to as CA) excessive or ouabain exist, can enhance this effect. (2) Membrane inhibition (ie