论文部分内容阅读
青蒿素是一个从中药艾草中提取出来的单体,在体内,对氯喹产生抗性的恶性疟原虫株具有明显的疗效;在体外和其衍生物双氢青蒿素等均有迅速抑制。~8H-异亮氨酸与恶性疟原虫相结合的作用。本文进一步描述青蒿素引起伯氏疟原虫超微结构的变化,并在体外观察用。~8H标记药物在感染恶性疟原虫的人红细胞内的定位情况。一、体内试验:体重18～20g的T.F.W.小鼠,每鼠接种伯氏疟原虫(K173)2×10~7个,4天后,一次皮下注射青蒿素10mg/kg,在治前及治后0.5～24小时,每次从小鼠尾部取血2滴,并用同一时期感染而不给药的小鼠血样作对照。
Artemisinin is a monomer extracted from Chinese herbal medicine wormwood, and has obvious curative effect on Plasmodium falciparum resistant to chloroquine in vivo. In vitro and its derivatives such as dihydroartemisinin are rapidly inhibited . ~ 8H-isoleucine and Plasmodium falciparum combined role. This article further describes the artemisinin-induced changes in the ultrastructure of Plasmodium berghei and in vitro observations. ~ 8H labeling of the drug in P. falciparum infected human red blood cell localization. In vivo test: TFW mice weighing 18-20g were inoculated with 2 × 10-7 mice per kilogram of Plasmodium berghei (K173). After 4 days, a subcutaneous injection of artemisinin 10mg / kg was given before and after treatment 0.5 to 24 hours, each time from the mouse tail blood 2 drops, and with the same period of infection without administration of blood samples of mice as a control.