目的:分析不明原发灶颈部转移癌(unknownprimarycervicalmetastaticcarcinoma,UPCMC)的治疗方法和失败原因,探讨其治疗策略。方法:探讨111例UPCMC的临床资料、治疗和转归,比较和分析不同治疗组的颈部控制率、原发灶治疗失败率及远期生存率。结果:全组原发灶出现率为10.8%(12/111),颈部控制率为36.9%,5年生存率为41.4%;影响预后的因素为颈部控制情况、N分期、原发灶控制情况;颈部控制率的影响因素为N分期与是否全颈放疗。结论:UPCMC应以放疗为主,部分放疗不敏感的N1、N2病例可采取放疗加手术的综合治疗;颈部以全颈放疗为佳;对潜在原发灶的治疗推荐采取选择性放疗。 Objective: To analyze the treatment and failure of unknown primary thoracic cervical cancer (UPCMC), and to explore its treatment strategy. Methods: The clinical data, treatment and prognosis of 111 cases of UPCMC were investigated. The neck control rate, failure rate of primary tumor treatment and long-term survival rate of different treatment groups were compared and analyzed. Results: The incidence rate of primary tumor was 10.8% (12/111), neck control rate was 36.9%, and 5-year survival rate was 41.4%. The prognostic factors were neck control, N stage, primary tumor Control; neck control rate factors for N stage and whether the whole neck radiotherapy. Conclusion: UPCMC should be mainly radiotherapy, partial radiotherapy is not sensitive to N1, N2 cases can take radiotherapy combined with surgery; Neck full neck radiotherapy is better; for the treatment of potential primary lesions recommended radiotherapy.