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目的了解甲型H1N1流感疫苗接种前后格林-巴利综合症(Guillain-Barre Snydrome,GBS)发病的流行病学变化,研究甲型H1N1流感疫苗接种对GBS发病的影响。方法采用前后比较的方法对河北省甲型H1N1流感疫苗大规模接种前(2006-2009年)、接种后(2010-2012年)GBS发病情况进行分析比较。结果河北省15岁以下儿童GBS在甲型H1N1流感疫苗接种前后均为男性多于女性;发病率以6岁以下的学龄前儿童最高,为1.18/10万;其次是6~11岁的小学生,发病率为0.57/10万;1~14岁初中学生发病率最低,为0.39/10万;疫苗接种后,GBS发病率在0.42/10万~0.57/10万间,平均发病率0.49/10万,较疫苗接种前GBS发病率下降54.2%,经比较差异有统计学意义(χ2=88.55,P<0.01);疫苗接种前后,GBS发病的季节构成经比较差异无统计学意义(χ2=2.24,P>0.05)。结论大规模接种甲型H1N1流感疫苗前后,河北省15岁以下儿童GBS发病的流行特征没有明显差异,建议进一步加强河北省15岁以下儿童GBS监测数据资料以及流感疫苗接种数据的收集,为研究GBS发病和流感疫苗的关联性提供参考。
Objective To investigate the epidemiological changes of Guillain-Barre Snydrome (GBS) before and after the vaccination of Influenza A (H1N1) and study the influence of Influenza A (H1N1) vaccination on the incidence of GBS. Methods Before and after comparison, the incidence of GBS before (2006-2009) and after inoculation (2010-2012) of Influenza A (H1N1) vaccines in Hebei Province was analyzed and compared. Results The GBS of children under 15 years old in Hebei province were more than the male before and after the vaccination of Influenza A (H1N1). The incidence of preschool children under the age of 6 was 1.18 / 100000, followed by the pupils aged 6 to 11, The incidence rate was 0.57 / 100000; the lowest incidence of junior middle school students aged 1-14 was 0.39 / 100000; After vaccination, the incidence of GBS was between 0.42 / 100000 and 0.57 / 100000 with an average incidence of 0.49 / The incidence of GBS was 54.2% lower than before vaccination (χ2 = 88.55, P <0.01). Before and after vaccination, there was no significant difference in the incidence of GBS (χ2 = 2.24, P > 0.05). Conclusion Before and after the large-scale vaccination of Influenza A (H1N1) vaccine, the prevalence of GBS in children under 15 years of age in Hebei Province was not significantly different. It is suggested that GBS monitoring data and influenza vaccination data should be further strengthened in children under 15 years old in Hebei Province. The incidence and incidence of influenza vaccine provide a reference.