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在研制胰岛素新剂型的工作中,作者利用栓剂直肠给药的特点用家兔对胰岛素栓直肠给药剂量(以降低血糖值为指标)进行了研究,结果初步表明胰岛素能从直肠吸收,但有效剂量较大(50 IU/kg-75 IU/kg)表面活性剂有显著促进作用,使剂量减小能获得适宜的治疗剂量。作者研究了 Tween-80等九种表面活性剂,观察了它们的降糖效果。其顺序为:NO-10>十二烷基硫酸钠>聚氧乙烯月桂醚(Brij 35)>聚氧乙烯蓖麻油>Cremophor EL>去氧胆酸>Cremophor RH40>卵磷脂>Tween-80
In the development of new dosage forms of insulin, the author used the characteristics of rectal administration of suppository with rabbit rectum insulin dose (to reduce blood glucose as an index) were studied, the results showed that insulin can be absorbed from the rectum, but effective A larger dose (50 IU / kg-75 IU / kg) surfactant has a significant role in promoting the dose can be reduced to obtain the appropriate therapeutic dose. The authors studied Tween-80 and other nine surfactants, observed their hypoglycemic effect. The order is: NO-10> sodium lauryl sulfate> Brij 35> polyoxyethylene castor oil> Cremophor EL> deoxycholic acid> Cremophor RH40> lecithin> Tween-80