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目的:探讨缺血性脑血管(ICVD)和心血管(CHD)疾病患者醛固酮(aldosterone,Ald)与内皮素(endo-thelin-1,ET-1)的关系。方法:缺血性脑血管病和心血管病及其相关组分诊断标准采用WHO及国家相关机构认可的工作定义。应用放射免疫分析,对93例缺血性脑血管病和103例冠心病患者进行了血清Ald和血浆ET-1的测定,与相同年龄对照组进行比较,并进行相关性分析。结果:①与正常人(62.52±10.40)pg/ml比较,ICVD和CHD各组Ald水平均显著增高,以高血压组(HBP)增高最为显著(89.69±30.11)pg/ml,两组Ald水平增高顺序为HBP>椎基底动脉供血不足(VBI)>急性脑梗死(ACI)>冠心病(CHD)>脑梗死后遗症(SCI)。②ET-1水平与对照组(58.25±12.2)pg/ml比较各组亦显著升高,HBP组ET-1为(80.29±18.35)pg/ml,相差极为显著(P<0.01),其中HBP>ACI>CHD>VBI>SCI。③线性回归分析显示,两组患者Ald与ET-1之间均呈明显正相关关系,其中ICVD组93例患者,血清Ald与血浆ET-1(r=0.459,P<0.01);HBP组Ald与ET-1(r=0.561,P<0.01);CHD组Ald与ET-1(r=0.20,P<0.05)。结论:Ald与ET-1与缺血性脑血管和心血管疾病的发生、发展密切相关,其浓度变化可作为评价心脑血管疾病时血管受损程度的客观指标。
Objective: To investigate the relationship between aldosterone (Ald) and endo-the-1 (ET-1) in patients with ischemic cerebrovascular disease (ICVD) and cardiovascular disease (CHD) Methods: The diagnostic criteria of ischemic cerebrovascular disease and cardiovascular disease and its related components were defined according to the working definition approved by WHO and relevant agencies of the country. Using radioimmunoassay, 93 patients with ischemic cerebrovascular disease and 103 patients with coronary heart disease were measured serum Ald and plasma ET-1, compared with the same age control group, and the correlation analysis. Results: (1) Compared with the normal control group (62.52 ± 10.40) pg / ml, the levels of Ald in ICVD and CHD groups were significantly increased (89.69 ± 30.11) pg / ml, The order of increase was HBP> VBI> ACI> CHD> SCI. (2) The ET-1 level in HBP group was significantly higher than that in control group (58.25 ± 12.2 pg / ml) (P <0.01), and the level of ET-1 in HBP group was (80.29 ± 18.35) pg / ACI> CHD> VBI> SCI. ③ Linear regression analysis showed that there was a significant positive correlation between Ald and ET-1 in both groups, including 93 patients in ICVD group, serum Ald and plasma ET-1 (r = 0.459, P <0.01) And ET-1 (r = 0.561, P <0.01). Aldosterone and ET-1 in CHD group (r = 0.20, P <0.05). Conclusion: Ald and ET-1 are closely related to the occurrence and development of ischemic cerebrovascular and cardiovascular diseases. The changes of concentrations of Ald and ET-1 may be used as objective indicators to evaluate the degree of vascular damage in cardiovascular and cerebrovascular diseases.