已有研究证实,口服亚硒酸钠能有效地预防克山病急性发病;用施钼肥的方法也可明显降低克山病病区人群发病率。但是有关硒和钼预防克山病发病的机制目前还不十分清楚。我们以前的研究证明,用克山病病区粮喂养的大白鼠心肌细胞膜通透性显著增大,表明病区粮中存在着可致心肌细胞膜损伤的因素。本研究的目的是观察克山病病区粮补充硒或钼对大白鼠心肌细胞膜通透性变化的影响,并藉以了解硒、钼与克山病发病之间的 Studies have confirmed that oral sodium selenite can effectively prevent the acute onset of Keshan disease; using molybdenum fertilizer can also significantly reduce the incidence of Keshan disease. However, the mechanisms by which selenium and molybdenum prevent Keshan disease are not yet clear. Our previous studies demonstrated that the membrane permeability of rat myocardial cells fed with food from Keshan disease was significantly increased, indicating that there is a factor that causes myocardial cell membrane damage in the ward food. The purpose of this study is to observe the effects of selenium or molybdenum supplementation on myocardial membrane permeability in rats with Keshan disease and to understand the relationship between selenium, molybdenum and Keshan disease