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应用环状免疫单扩散法及免疫组化技术对44例喉癌病人血清及32例癌组织进行血清DBP异质性和组织PCNA表达检测,发现各期喉癌病人血清中均存在DBP异常表达,并与化疗及复发有关;而与分型、淋巴结转移及病理分化无关;且血清DBP阳性喉癌组织中PCNA的表达率较高。提示它有较高的增殖活性,血清DBP异质性与喉癌的发生发展有密切关系。
Cytological DBP heterogeneity and tissue PCNA expression in 44 cases of laryngeal cancer patients and 32 cases of cancerous tissues were detected by cyclic immunodiffusion and immunohistochemistry. It was found that there was abnormal expression of DBP in serum of all laryngeal cancer patients, And was associated with chemotherapy and relapse; but not with the type, lymph node metastasis and pathological differentiation; and the positive rate of PCNA in serum of DBP-positive laryngeal cancer was higher. Suggesting that it has a higher proliferative activity, serum DBP heterogeneity and the occurrence and development of laryngeal cancer are closely related.