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目的:以24 h尿碘为参照,对学龄儿童晨尿碘浓度这一指标在碘缺乏病监测中的应用进行探讨,并与育龄妇女相应指标进行比较。方法:以同一地区8~10岁学龄儿童和育龄妇女为目标人群,尽量选择既有儿童又有育龄妇女的家庭户,同时收集两类人群晨尿和连续两天24 h尿,并分别测定其尿碘浓度。结果:儿童晨尿、第1天24 h尿、第2天24 h尿的碘浓度分别为(344±210)μg/L、(318±177)μg/L、(306±144)μg/L,妇女则为(366±232)μg/L、(321±151)μg/L、(366±160)μg/L。161例儿童与149例妇女连续两天24 h尿之间的碘浓度均呈正相关,差异有统计学意义(儿童:r=0.394,Pr<0.001;妇女:r=0.380,Pr<0.001)。不同人群晨尿和一天24 h尿的碘浓度均数均呈正相关,差异有统计学意义(儿童:r=0.297,Pr<0.001;妇女:r=0.281,Pr<0.001)。同一家庭户的学龄儿童和妇女之间的晨尿及24 h尿中碘浓度呈正相关,差异有统计学意义(晨尿:r=0.366,Pr<0.001;24 h尿:r=0.360,Pr<0.001)。结论:不同人群24 h尿中碘浓度平均水平在一段时期内较为稳定,晨尿的碘浓度能反映相应人群近期的碘水平,可用学龄儿童晨尿的碘浓度平均水平评价同地区不包括孕妇及哺乳妇女的育龄妇女的碘状态。
OBJECTIVE: To explore the application of urinary iodine for 24 hours in monitoring the iodine concentration of morning urine in school-age children in the monitoring of iodine deficiency disorders, and to compare with the corresponding indicators of women of childbearing age. Methods: The target population of school-age children aged 8-10 and women of childbearing age in the same area were selected as the target population. The families with both children and women of childbearing age were selected as far as possible. Morning urine of two groups and urine of 24 hours were collected for two consecutive days. Urinary iodine concentration. Results: The urinary iodine concentrations of morning urine in children, urinary 24 h urine on the first day and 24 h urine on the second day were (344 ± 210) μg / L, (318 ± 177) μg / L and (306 ± 144) μg / L (366 ± 232) μg / L, (321 ± 151) μg / L, and (366 ± 160) μg / L for women, respectively. There was a positive correlation between iodine concentrations in urine of 161 children and 149 women for 24 days (odds ratio: r = 0.394, Pr <0.001; women: r = 0.380, Pr0.001). There was a positive correlation between morning urine in different groups and urinary iodine concentration 24 hours a day (children: r = 0.297, Pr <0.001; women: r = 0.281, Pr0.001). There was a positive correlation between morning urine and urine iodine concentration in 24 h urine of school-age children and women in the same household (morning urine: r = 0.366, Pr <0.001; 24 h urine: r = 0.360, Pr < 0.001). Conclusion: The average level of urinary iodine in 24-hour urine of different groups is stable over a period of time. The morning urine iodine concentration can reflect the recent iodine level of the corresponding population. The morning urine iodine level of school-age children can be used to evaluate the average level of iodine in pregnant women, Iodine status of breastfeeding women of childbearing age.