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将102例2型糖尿病合并周围神经病变患者随机分为治疗组52例和对照组50例。治疗组予硫辛酸600mg静滴,甲钴铵1000μg静滴;对照组仅予甲钴铵1000μg/d静滴,疗程均14d。结果治疗组显效33例,有效14例,总有效率90.0%;对照组显效19例,有效15例,总有效率68.0%,两组总有效率比较,P<0.01;两组治疗期间均无明显不良反应。结论硫辛酸联合甲钴胺治疗2型糖尿病性周围神经病疗效确切,且安全性高。
102 patients with type 2 diabetes mellitus and peripheral neuropathy were randomly divided into treatment group (n = 52) and control group (n = 50). In the treatment group, 600 mg of intravenous lipoic acid and 1000 μg of mecobalamin were intravenously administered. In the control group, intravenous administration of 1000 μg / d of mecobalamin was given only for 14 days. Results In the treatment group, 33 cases were markedly effective and 14 cases were effective. The total effective rate was 90.0%. In the control group, 19 cases were markedly effective and 15 cases were effective. The total effective rate was 68.0%. There was no significant difference between the two groups (P <0.01) Obvious adverse reaction. Conclusion The combination of lipoic acid and mecobalamin in the treatment of type 2 diabetic peripheral neuropathy is effective and safe.