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随机选择52例好高征患者,20名健康未孕妇女,30例正常妊娠妇女用放射免疫测定法测定血浆降钙素基因相关肽(CGRP)水平。结果表明:妊娠组与未孕组之间CGRP含量差异显著(P<0.01);妊高征组血浆CGRP显著高于妊娠组(P<0.01),提示:妊娠期高水平的CGRP是孕期血容量和红细胞升高反应的代偿机制。妊高征患者血浆CGRP含量增高可能与血管内皮系统的适应性和代偿性变化有关。但在重症好高征特别是子痫时血浆水平则明显下降。因此,血浆CGRP水平变化可能是诊断妊高征的一个指标。
Totally 52 patients with hyperhortic syndrome, 20 healthy and non-pregnant women and 30 normal pregnant women were randomly selected to detect the level of plasma calcitonin gene-related peptide (CGRP) by radioimmunoassay. The results showed that the content of CGRP in pregnancy group was significantly higher than that in non-pregnant group (P <0.01). The plasma CGRP level in PIH group was significantly higher than that in pregnancy group (P <0.01), suggesting that high levels of CGRP Is compensatory mechanism of blood volume during pregnancy and erythrocyte elevation response. Patients with PIH plasma CGRP levels may be related to vascular endothelial system adaptability and compensatory changes. However, in the case of severe acute exacerbations, especially in eclampsia, plasma levels are significantly decreased. Therefore, changes in plasma CGRP levels may be an indicator of PIH.