论文部分内容阅读
目的 探讨胰血管活性肠肽瘤 (VIPoma)的诊断与治疗经验。方法 应用放射免疫分析法检测术前、术后病人血VIP浓度及其它消化道激素水平 ;应用免疫组化染色了解肿瘤组织中VIP的表达 ;肿瘤细胞原代培养 ,了解培养液中VIP的浓度 ;应用生长抑素治疗 ,观察临床疗效。结果 (1)肿瘤切除后 ,水泻、低血钾和胃酸缺乏三联征 (WDHA)消失 ;(2 )术后血VIP浓度呈动态下降 ;(3)肿瘤细胞原代培养液VIP浓度明显增高 ;(4 )肿瘤组织免疫组化染色VIP有较强表达 ;(5 )生长抑素对改善WDHA症状有显著作用。结论 典型的临床症状及血浆VIP测定是VIPoma诊断的关键 ,治疗以手术切除为主 ,生长抑素对控制症状有明显疗效。
Objective To investigate the diagnosis and treatment of pancreatic vasoactive intestinal peptide tumor (VIPoma). Methods Preoperative and postoperative serum VIP levels and other gastrointestinal hormone levels were measured by radioimmunoassay. Expression of VIP in tumor tissue was detected by immunohistochemical staining. Primary tumor cells were cultured to understand the concentration of VIP. Application of somatostatin treatment, observation of clinical efficacy. Results (1) WDHA disappeared after tumor resection; (2) VIP serum concentration decreased dynamically; (3) VIP concentration in primary culture medium of tumor cells was significantly increased; (4) Immunohistochemical staining of tumor tissues showed strong expression of VIP; (5) Somatostatin had a significant effect on the improvement of symptoms of WDHA. Conclusions The typical clinical symptoms and plasma VIP assay are the key to the diagnosis of VIPoma. Surgical resection is the main treatment and somatostatin has obvious curative effect on the control of symptoms.