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腺苷是严重创伤及组织缺血缺氧时释放的重要内源性调质,主要通过腺苷受体发挥作用。血管平滑肌上主要有4种腺苷受体亚型(A1AR,A2aAR,A2bAR及A3AR),其中A1AR和/或A3AR活性及其偶联信号活性的抑制,或A2aAR和/或A2bAR活性及其偶联信号活性的上调,或两者同时发生,通过Rho激酶和/或PKC依赖信号通路,参与对血管MLC磷酸化及钙敏感性调节,并在休克血管低反应性中起重要作用。
Adenosine is an important endogenous quencher that is released during severe trauma and tissue ischemia and hypoxia and functions mainly through adenosine receptors. There are four major adenosine receptor subtypes (A1AR, A2aAR, A2bAR and A3AR) on vascular smooth muscle, in which inhibition of A1AR and / or A3AR activity and its coupling signal activity or A2aAR and / or A2bAR activity and its coupling Upregulation of signal activity, or both, is involved in the regulation of phosphorylation and calcium sensitivity of vascular MLC through Rho kinase and / or PKC-dependent signaling and plays an important role in shock vascular hyporeactivity.