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目的:探究西宁地区不同妊娠时期妇女甲状腺相关激素水平和妊娠期甲状腺疾病的发病率,为预防妊娠期妇女甲状腺疾病提供理论依据。方法:500例不同妊娠期妇女(妊娠组),其中妊娠<12周末(妊娠早期组)180例,妊娠(13~27)周末(妊娠中期组)165例,妊娠≥28周末(妊娠晚期组)155例,常规健康体检非妊娠妇女180例作为非妊娠组。比较各组血清甲状腺激素水平,观察比较妊娠组与非妊娠组女性甲状腺疾病发病率。结果:妊娠组女性的甲状腺发病率明显高于非妊娠组女性;妊娠组女性FT3和FT4水平明显高于非妊娠组,TSH水平低于非妊娠组,随着妊娠时间延长,促甲状腺激素(TSH)逐渐上升,游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)水平逐渐下降,组间比较差异有统计学意义(P<0.05)。结论:西宁地区妊娠组女性的甲状腺发病率明显高于非妊娠组女性,妊娠合并甲状腺疾病对妊娠结局和胎儿存在一定不良影响,应在孕前或孕早期进行血清甲状腺激素水平筛查并干预,降低不良妊娠结局的发生,提高孕妇的妊娠质量。
Objective: To investigate the thyroid-related hormones and the incidence of thyroid disease in pregnant women in different gestation stages in Xining, and to provide a theoretical basis for the prevention of thyroid diseases in pregnant women. Methods: A total of 500 pregnant women of different pregnancy groups (pregnancy group) were enrolled. Among them, 180 were pregnant <12 weeks old (early pregnancy), 165 were pregnant (13-27) 155 cases, 180 cases of non-pregnant women in routine physical examination as non-pregnant group. Thyroid hormone levels in each group were compared, and the incidence of thyroid diseases in pregnant women and non-pregnant women was compared. Results: The incidence of thyroid in pregnant women was significantly higher than that in non-pregnant women. The levels of FT3 and FT4 in pregnant women were significantly higher than those in non-pregnant women, while the levels of TSH were lower than those in non-pregnant women. With prolonged pregnancy, thyroid-stimulating hormone ) Gradually increased. The levels of free triiodothyronine (FT3) and free thyroxine (FT4) gradually decreased. There was significant difference between the two groups (P <0.05). Conclusion: The incidence of thyroid in pregnant women in Xining area is significantly higher than that in non-pregnant women. Pregnancy with thyroid disease has some adverse effects on pregnancy outcome and fetus. Serum thyroid hormone levels should be screened and intervened before and during pregnancy to decrease Adverse pregnancy outcome, improve pregnant women’s pregnancy quality.