血卟啉衍生物(HpD)是一种强光敏剂,它具有选择性分布定位在癌组织的特点。在一定波长可见光的激发下,HpD可发出特征性红色荧光,有助于对癌瘤的诊断;同时,它又能发生光化学反应,从而杀死癌细胞。本文研究了HpD-激光对体外培养的人胃低分化粘液腺癌细胞系MGc80-3的杀伤效应,探讨光敏杀伤的机制。 Hematoporphyrin derivative (HpD) is a strong photosensitizer that has a selective distribution characteristic of cancerous tissues. Under the excitation of visible light at a certain wavelength, HpD emits characteristic red fluorescence, which is helpful for the diagnosis of cancerous tumors. At the same time, it can also undergo photochemical reactions that kill cancer cells. This paper studied the killing effect of HpD-laser on human gastric poorly differentiated mucinous adenocarcinoma cell line MGc80-3 in vitro, and explored the mechanism of photosensitization.