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目的探讨甲状腺功能亢进症(甲亢)患者肝功能指标的变化,了解甲亢患者肝功能损害程度,为临床治疗提供依据。方法采用罗氏Cobas.c702和罗氏电化学发光E170分别检测80例甲亢患者甲功五项和肝功能指标变化。结果与60例健康查体者结果比对分析。结果甲亢组的FT4和FT3均高于对照组,TSH低于对照组,差异均有统计学意义(P<0.01);甲亢组血清ALT,AST,TBIL,DBIL,ALP,GGT高于对照组,TP,ALB低于对照组,差异均有统计学意义(P<0.01)。结论甲亢患者常伴随有肝功能损害的临床表现,常规检测甲亢患者肝功能指标对指导临床治疗及预后观察具有重要意义。
Objective To investigate the changes of liver function indexes in patients with hyperthyroidism (Hyperthyroidism) and to understand the degree of liver dysfunction in patients with hyperthyroidism and provide the basis for clinical treatment. Methods Routine Cobas.c702 and Roche electrochemiluminescence E170 were used to detect the changes of five indexes of thyroid function and liver function in 80 patients with hyperthyroidism. Results and 60 cases of physical examination results comparison analysis. Results The serum levels of ALT, AST, TBIL, DBIL, ALP and GGT in hyperthyroidism group were higher than those in control group, and the levels of TSH in hyperthyroidism group were higher than those in control group (P <0.01) TP, ALB lower than the control group, the difference was statistically significant (P <0.01). Conclusion The patients with hyperthyroidism are often accompanied by the clinical manifestations of liver dysfunction. The routine examination of liver function indexes in patients with hyperthyroidism is of great significance in guiding the clinical treatment and prognosis observation.