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本研究旨在阐明:(1)给予致死量的乙醇后,Zn是否能提高中毒动物的存活率;(2)急性和慢性给予Zn对肝ADH活性有无影响。实验动物为雄性ICR小鼠,体重20～25g。在急性实验中,乙醇和Zn的给药方式均系腹腔注射;慢性实验,Zn通过饮水给予。取腹主动脉血液供血浆Zn水平及血液乙醇含量的测定。观察指标包括:5天存活率、血乙醇含量、血浆Zn水平及肝ADH活性。实验1的结果表明,在给小鼠一次注射致
The purpose of this study is to clarify whether: (1) whether Zn can increase the survival rate of infected animals after given lethal dose of ethanol; and (2) whether acute or chronic Zn administration has any effect on hepatic ADH activity. Experimental animals for male ICR mice, weighing 20 ~ 25g. In acute experiments, ethanol and Zn were administered intraperitoneally; in chronic experiments, Zn was given by drinking water. Take the abdominal aorta for plasma Zn levels and blood alcohol content determination. Observational indicators include: 5-day survival, blood alcohol content, plasma Zn levels and hepatic ADH activity. The results of experiment 1 show that after a single injection of the mouse