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目的:研究约旦皇家医疗服务医院中突发恶性眼周肿瘤的发病率、流行病学及临床特征。方法:回顾性研究。回顾分析我院在2004~2015年收治的327例诊断为恶性眼周肿瘤患者的病历资料。研究参数包括年龄、性别、患者所在城市、现病史(非肿瘤引起或与肿瘤相关的)、临床与病理诊断、肿瘤大小、位置及手术方式等。结果:在327例患者中,46例(14.1%)患者诊断出患有突发恶性眼周肿瘤。男性与女性的患病比例为2:1。平均年龄为66.39±10.59(22-83)岁。最常见的临床疾病或症状为白内障致视觉模糊(44%),其次为白内障合并其他相关症状类似泪溢症等(21.7%)。初步临床诊断联合病理诊断95.7%为皮肤癌。平均病变大小为1.04×0.85(0.2×0.2~3.0×3.0)mm~2。肿瘤的最大直径和患者年龄无明显关系(P=0.105)。最常见的肿瘤位于下眼睑(30.4%),其次为内眦处(26.1%)。随访时间6mo至3a(平均9.3mo)。结论:突发恶性眼周肿瘤在本研究中较为常见,任何可疑病灶须尽快切除。一些患者忽视这些病变的原因需要进一步的前瞻性研究分析。
OBJECTIVE: To study the incidence, epidemiology and clinical features of sudden malignant ocular tumors in the Royal Jordanian Hospital of Medical Services. Methods: Retrospective study. A retrospective analysis of our hospital in the 2004 to 2015 admitted 327 cases of patients with malignant peripheral ophthalmology records. The study parameters include age, sex, city of the patient, current medical history (non-tumor-related or tumor-related), clinical and pathological diagnosis, tumor size, location, and surgical modalities. RESULTS: Out of 327 patients, 46 (14.1%) of the patients were diagnosed with sudden malignant periocular tumors. The prevalence of males to females is 2: 1. The average age was 66.39 ± 10.59 (22-83) years old. The most common clinical disease or symptoms were cataract-induced visual acuity (44%), followed by cataract with other related symptoms such as teratology (21.7%). Preliminary clinical diagnosis combined with pathological diagnosis of 95.7% of skin cancer. The average lesion size was 1.04 × 0.85 (0.2 × 0.2 ~ 3.0 × 3.0) mm ~ 2. There was no significant correlation between the maximum tumor diameter and the patient’s age (P = 0.105). The most common tumors were located in the lower eyelid (30.4%), followed by the infraorbital (26.1%). Follow-up time 6mo to 3a (average 9.3mo). Conclusions: Sudden malignant periocular tumors are more common in this study, and any suspicious lesions should be resected as soon as possible. Some patients ignore the reasons for these lesions need further prospective study.