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糖尿病是合并心血管疾病患者预后不良的强预测因子。他汀类、噻嗪类利尿剂、β受体阻滞剂为常用心血管药物，它们能够降低糖尿病患者的心血管风险，然而也增加新发糖尿病风险。尽管存在不同假说，药物相关的新发糖尿病发生机制仍不明确。对于有新发糖尿病高风险患者，应充分评估药物的心血管获益和新发糖尿病风险。膳食管理和运动组成的生活方式干预，可以降低新发糖尿病风险，联合用药也可能降低新发糖尿病风险。“,”Diabetes is a strong adverse prognostic factor for patients with cardiovascular ( CV) disease. Statins,thiazide diuretics and βblockers are commonly used for controlling blood pressure .They reduces CV risk in patients with diabetes.However, they have been shown to increase the risk of new-onset diabetes ( NOD) .The mechanisms whereby these drugs increasing the risk of NOD are incompletely understood , although different hypotheses have been proposed.Benefit in terms of CV event reduction and increased risk of NOD should be assessed before use of these cardiovascular drugs,particularly in patients at high risk of NOD.Lifestyle intervention consisting of diet and exercise has been shown to reduce the risk of NOD ,and combined medication might reduce the risk of NOD .