喹啉酮衍生物具有明显的生理活性［１］。一般合成方法是将β－酮酸酯与芳胺反应，首先生成β－酮酰胺，继而在浓硫酸存在下加热闭环，生成４－烃基－２－喹啉酮［２～４］。虽然多种４－甲基及４－芳基－２－喹啉酮用此法合成，但合成其他４－烃基取代的２－喹啉酮报道甚少， Quinolinone derivatives have obvious physiological activity [1]. The general method of synthesis is the reaction of β-keto esters with aromatic amines to generate β-ketoamides first, followed by heating and ring closure in the presence of concentrated sulfuric acid to produce 4-hydrocarbyl-2-quinolinones [2-4]. Although many 4-methyl and 4-aryl-2-quinolinones have been synthesized by this method, few reports on the synthesis of other 4-hydrocarbyl substituted 2-quinolones,