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目的探讨转化生长因子-β1(TGF-β1)在急性白血病中的临床意义。方法采用酶联免疫法(ELISA)测定68例急性白血病患者血清及骨髓中TGF-β1水平。结果急性白血病初诊患者血清及骨髓TGF-β1水平明显低于正常对照组(P<0.05),完全缓解期TGF-β1水平恢复正常,未缓解和复发患者TGF-β1水平与初诊患者无明显差异(P>0.05)。结论检测TGF-β1水平变化有助于急性白血病病情判断,可作为疗效观察的辅助指标。
Objective To investigate the clinical significance of transforming growth factor-β1 (TGF-β1) in acute leukemia. Methods The levels of TGF-β1 in serum and bone marrow of 68 patients with acute leukemia were determined by enzyme-linked immunosorbent assay (ELISA). Results The levels of TGF-β1 in serum and bone marrow of newly diagnosed acute leukemia patients were significantly lower than those in normal control group (P <0.05). TGF-β1 levels returned to normal in complete remission stage. There was no significant difference in TGF-β1 levels between newly diagnosed and untreated patients P> 0.05). Conclusion Detection of TGF-β1 changes in the level of acute leukemia contribute to the judgment, can be used as a secondary indicator of efficacy.