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[目的]探讨大剂量洛赛克联用善宁治疗难治性上消化道出血的疗效。[方法]111例患者随机分为治疗组(56例)和对照组(55例)。2组均用善宁0.1mg静脉注射后,以25μg/h微量泵持续静脉推注,出血停止后维持48h。治疗组同时应用洛赛克80mg静脉缓慢推注,继之以8mg/h微量泵持续静脉推注;对照组同时应用洛赛克40mg静脉推注,继之以4mg/h微量泵持续静脉推注。2组均于出血停止后维持48h。[结果]治疗组显效率及总有效率均高于对照组(均P<0.05);2组急性静脉曲张性上消化道出血疗效差异无统计学意义,急性非静脉曲张性上消化道出血总有效率差异有统计学意义(P<0.01)。[结论]大剂量洛赛克联用善宁治疗难治性上消化道出血疗效优于常规剂量。
[Objective] To investigate the effect of high dose Losec combined with Shanning on refractory upper gastrointestinal bleeding. [Method] 111 patients were randomly divided into treatment group (56 cases) and control group (55 cases). Both groups were given Shinning 0.1mg intravenous injection with 25μg / h micro-pump sustained intravenous injection, bleeding to maintain 48h after stopping. The treatment group also applied Losec 80mg intravenous bolus injection, followed by continuous intravenous injection of 8mg / h trace pump; the control group at the same time with intravenous injection of 40mg Losec, followed by continuous intravenous injection of 4mg / h trace pump . The two groups were maintained for 48h after the bleeding stopped. [Results] The effective rate and total effective rate of the treatment group were significantly higher than those of the control group (all P <0.05). There was no significant difference in the curative effect between the two groups of acute varicose upper gastrointestinal bleeding. The acute non-variceal upper gastrointestinal bleeding The difference was statistically significant (P <0.01). [Conclusion] The high dose of Losec and Shanning is superior to conventional dose in the treatment of refractory upper gastrointestinal bleeding.